Suspected FIP? Try the reverse trial with GS-441.

Feline Infectious Peritonitis (FIP) is a serious disease with a high fatality rate, expensive treatment, and concerns for cat owners.

Diagnosing FIP is challenging, as there is no definitive test. However, certain tests can indicate a high suspicion of FIP if the results align with FIP indicators and the cat exhibits compatible symptoms. This diagnosis is referred to as “highly suspected FIP.”

To confirm an FIP diagnosis, a “reverse trial” approach using the targeted drug GS-441 is employed. Cats with FIP typically show noticeable improvement within 3-7 days after receiving GS-441. This “reverse trial” approach helps confirm the FIP diagnosis.

Suspected FIP? Try the reverse trial with GS-441.


Diagnosing wet FIP is relatively easier, and the risk is lower during the “reverse trial.” However, diagnosing dry FIP is more challenging and prone to misdiagnosis with other diseases, posing some risks during the “reverse trial.”

A correct “reverse trial” with GS-441 helps treat the disease effectively, while an incorrect trial does not harm the cat but may delay the true diagnosis and appropriate treatment.

Therefore, when considering a “reverse trial” with GS-441, caution and awareness of the risks are important. It should be based on the actual circumstances. Two situations where a “reverse trial” can be attempted are:

  1. Dissimilar test results but similar symptoms: When test results do not conclusively indicate FIP but the cat shows typical FIP symptoms, such as fluid accumulation in the chest or abdomen, ocular abnormalities, or coordination issues. After observing the cat’s response for about a week following GS-441 treatment, a confirmed FIP diagnosis can be made if there is significant improvement. Otherwise, other diseases should be investigated and treated.
  2. Suspicious test results but atypical symptoms: When test results strongly suggest FIP, such as low globulin levels, positive coronavirus test, or evident inflammation, but the cat does not exhibit significant symptoms. In such cases, a “reverse trial” with GS-441 can be attempted. Again, observing the cat’s response for about a week helps determine whether to continue FIP treatment based on improvement or explore other potential diseases.

In conclusion, diagnosing FIP is challenging. Whether a cat is highly suspected of having FIP or requires a “reverse trial” with GS-441, pet owners should closely observe their cat’s condition and promptly communicate with veterinarians and medication providers if any abnormalities are noticed.

If you have any further questions about FIP, please feel free to comment or leave a message below, and we will respond as soon as possible.

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